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Animal studies allow us to find out about initiating events in this process. A further limitation of animal studies is that issues of control and choice, which play a major role in human feeding from an early age forward, are not and frequently cannot be addressed. In addition to the blockade of insulin and leptin effects, the high fat diet-fed animals showed an increase in sucrose self-administration relative to low fat chow-fed controls. Regardless of how obesity is achieved, the disorder becomes a metabolic one, and the new body weight is defended both metabolically and behaviorally through the actions of peripheral metabolic signaling and its interactions with hypothalamic homeostatic regulation of feeding. Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions. Quiero un activo guebon que me de duro, tengo lugar.